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"You've got to be constantly looking forward," Schleifer said. "We think we have an exciting pipeline. That's the only Converse All Star Black Leather Mono

returning vision. That's the holy grail in vision," Schleifer said.

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Critics doubted whether his company would ever discover a marketable drug and become profitable.

"Regeneron was at its best when it didn't know where the lifeblood of money was coming from.

´╗┐From snow shoveler to billionaire CEO

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Today Schleifer tries to maintain the innovative spirit that drove those frantic early years at Regeneron and his first job.

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"People who didn't have enough vision to read to their grandchildren might be able to read," Schleifer said. "It's obviously enormously satisfying and gratifying. There's no greater reward than to know your products are making a difference."

He likes to tell visitors that he and founding scientist George Yancopoulos need to be as excited about an experimental drug that has virtually no chance of hitting the market as they are about the latest Eylea sales figures.

"This is what we were spending our lives trying to accomplish. Converse Mens Boots

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He honed his deal making skills while running a snow shoveling business as a young man growing up in Rego Park, Queens.

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"We were never in this for the quick fix. This isn't the software business where you could write a program, everybody loves it and before you know it, you're on top of the world," Schleifer said. "We're doing something that is pretty darn difficult."

Regeneron's hot stock price (it's the best S 500 performer over the past three years), has been fueled by the success of Eylea as well as a growing sense that the company has one Converse Boots Brown of the industry's deepest pipelines of drugs in development.

The science involved is undoubtedly complex, but Schleifer also deserves credit for forging smart alliances. Regeneron's 2003 partnership with multi national pharmaceutical company Sanofi freed the company up to invest more on new drug development.

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"When you have to do a whole block's worth of shoveling, you get a lot of experience" negotiating, he said.

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Eylea, which generated more than $800 million in sales during its first year on the market, carries a limited period of exclusivity before generic alternatives begin eating into sales.

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thing you have in this business because the current drugs aren't the ones you will be selling 10 years from now."

Today, Schleifer and his colleagues are motivated by the ability to create drugs that can improve people's lives.

His success was hardly assured when he founded the company. He went through decades of failure when Regeneron struggled to stay afloat.

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Schleifer is a licensed physician with a certification in neurology, but it takes more than education and training to be successful as a biotech.

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